Gene tests and brain imaging reveal early dementia
Dementia diseases develop insidiously and are generally discovered when the memory has already started to deteriorate. New research form Karolinska Institutet shows, however, that approaching Alzheimers can be detected several years before the symptoms manifest themselves.
Dementia involves a serious deterioration of mental function caused by some kind of dementia disease of the brain, of which Alzheimers is the most common. Although there is currently no cure for Alzheimers, it is possible to inhibit its development if the treatment is given early enough. However, with todays diagnostics, it is very difficult to identify people with early Alzheimers.
A new doctoral thesis by Johanna Lind, Karolinska Institutet, now shows that genetic mapping and brain imagery can be used to identify people who will develop dementia even before any clinical symptoms appear.
This is a crucial step towards the better diagnosis of Alzheimers,” she says. If the method is developed it can help us find the people whod benefit most from treatment in good time.”
The method is based on the well-established fact that the APOE protein affects the risk of developing Alzheimers. APOE is a lipid-transporting protein important in, amongst other things, the repair of cerebral neurons. Roughly one person in five carries a genetically determined variant of APOE that is associated with an increased risk of Alzheimers.
In her study, Ms Lind was able to show that some of the people in this risk group had reduced parietal lobe activity, detectable using an MR camera, and that these same people were the ones who went on to suffer memory deterioration two to three years later.
Its surprisingly difficult to diagnose Alzheimers with any certainty, but things are made easier if you know who runs the greatest risk,” she says. If genetic mapping, MRI and cognitive tests all suggest approaching Alzheimers, it might be an idea to start a course of treatment.”
Thesis: Memory, genes, and brain imaging: relating the APOE gene to brain function and structure
For further information, please contact:
PhD Johanna Lind
Department of Clinical Neuroscience
Tel: +46 (0)8-51776108 or +46(0)70-5396979 (mobile)
Press Officer Katarina Sternudd
Tel: +46 (0)8-524 838 95 or +46 (0)70-224 38 95 (mobile)
Karolinska Institutet is one of the leading medical universities in Europe. Through research, education and information, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine. For more information, visit ki.se